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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1978-9-15
|
| pubmed:abstractText |
Oxatomide or R 35443, 1-(3-[4-(diphenylmethyl)-1-piperazinyl]propyl)-1,3-dihydro--2H-benzimidazol-2-one, a compound with potent antihistaminic and anti-anaphylactic activities, shows specific antiserotonin effects on isolated caudal arteries of the rat. In vivo it is a powerful antagonist of bronchospasm induced by serotonin and by histamine; it has no anticholinergic effects and does not affect blood pressure in spontaneously hypertensive rats. These antiserotonin properties of oxatomide may contribute significantly to its anti-allergic activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0301-4533
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
232
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
217-20
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:28094-Animals,
pubmed-meshheading:28094-Arteries,
pubmed-meshheading:28094-Blood Pressure,
pubmed-meshheading:28094-Bronchi,
pubmed-meshheading:28094-Guinea Pigs,
pubmed-meshheading:28094-Histamine H1 Antagonists,
pubmed-meshheading:28094-Male,
pubmed-meshheading:28094-Methacholine Compounds,
pubmed-meshheading:28094-Muscle Contraction,
pubmed-meshheading:28094-Piperazines,
pubmed-meshheading:28094-Rats,
pubmed-meshheading:28094-Serotonin Antagonists,
pubmed-meshheading:28094-Time Factors
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|