Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0028066,
umls-concept:C0030011,
umls-concept:C0030685,
umls-concept:C0031327,
umls-concept:C0039225,
umls-concept:C0240339,
umls-concept:C0332120,
umls-concept:C0391871,
umls-concept:C0439834,
umls-concept:C0680255,
umls-concept:C0681850,
umls-concept:C1283071,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1882417,
umls-concept:C1963578,
umls-concept:C2349001,
umls-concept:C2697811
|
| pubmed:issue |
9
|
| pubmed:dateCreated |
1989-12-19
|
| pubmed:abstractText |
Nifedipine kinetics after ingestion of 20 mg slow release tablets were studied in 12 young, healthy, Mexican subjects. Plasma levels were determined by a nifedipine-specific HPLC assay. Levels rose after drug administration reaching a maximum concentration of 48.7 +/- 7.3 ng/ml in 2.1 +/- 0.7 h (mean +/- SEM). Concentrations then decayed with a terminal half-life of 16.9 +/- 3.1 hours. AUC was 526 +/- 62 ng h/ml. Five individuals were fast and seven were slow nifedipine metabolizers, according to the AUC criterion proposed by Kleinbloesem and coworkers. Individual AUC/Dose values from this and from other two studies on oral nifedipine kinetics in Mexicans were cumulated and the frequency histogram and probit analyses were performed (N = 30). A bimodal distribution was clearly observed. Fast and slow metabolizers were distinguished as those subjects with AUC/Dose values either lower or higher than 22.5 ng h/ml mg. Unlike European populations, it appears that slow metabolization is more frequent in Mexicans. Data strongly support the hypothesis of the existence of a polymorphism concerning nifedipine disposition kinetics due to genetic basis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0091-2700
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
816-20
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2808746-Adult,
pubmed-meshheading:2808746-Chromatography, High Pressure Liquid,
pubmed-meshheading:2808746-Delayed-Action Preparations,
pubmed-meshheading:2808746-Humans,
pubmed-meshheading:2808746-Male,
pubmed-meshheading:2808746-Mexico,
pubmed-meshheading:2808746-Nifedipine,
pubmed-meshheading:2808746-Oxidation-Reduction,
pubmed-meshheading:2808746-Phenotype,
pubmed-meshheading:2808746-Vasodilation
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Pharmacokinetics of nifedipine slow release tablet in Mexican subjects: further evidence for an oxidation polymorphism.
|
| pubmed:affiliation |
Depto. de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del I.P.N., Mexico City, Mexico.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|