Linked Life Data

2808690

Source:http://linkedlifedata.com/resource/pubmed/id/2808690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-12-19
pubmed:abstractText
We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate into the parenchyma of the neuraxis of neonatal rats and to establish much higher concentrations than was found in mature rats. Immunohistochemical studies revealed no evidence of significant extravasation of serum proteins from the vasculature. For any given survival interval studied, there was no significant difference in appearance and intensity of immunohistochemical staining or the amount of radiolabeled IgG measured between different areas of the brain and spinal cord. Electrophoresis of radioactive proteins extracted from the brains of neonatal rats injected with radiolabeled IgG confirmed that IgG penetrates into the brain parenchyma as the whole molecule. These results validate the use of systemically administered rabbit IgG for studies of brain development in neonatal rats. They also have implications for the pathogenesis of congenital central nervous system anomalies in which maternal autoimmune IgG may affect brain development after being transferred to the fetus or neonate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Time course of penetration of xenogeneic IgG into the central nervous system of the neonatal rat: an immunohistochemical and radionuclide tracer study.
pubmed:affiliation
Department of Neurology, University of Texas Medical Branch, Galveston, 77550.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't