Linked Life Data

2806385

Source:http://linkedlifedata.com/resource/pubmed/id/2806385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1989-12-20
pubmed:abstractText
We used a combination of radioreceptor binding and autoradiographic techniques to study the pharmacological characteristics and anatomical localization of [3H]quinuclidinyl benzylate (QNB) in kidney sections of Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). [3H]QNB was bound by sections of rat kidney in a manner consistent with the labeling of muscarinic acetylcholine receptors. Anatomically, these receptor sites were located primarily within the smooth muscle of the renal vascular tree and to a lesser extent within cortical and medullary tubules. The density of renal muscarinic acetylcholine receptors (both vascular and tubular) was decreased in hypertension but the affinity of the ligand for muscarinic receptors was unchanged. A possible role of muscarinic acetylcholine receptors in renal function is suggested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
297-305
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Autoradiographic localization of muscarinic receptors within the rat kidney.
pubmed:affiliation
Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma, Italy.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't