Linked Life Data

2806047

Source:http://linkedlifedata.com/resource/pubmed/id/2806047

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-12-8
pubmed:abstractText
131I-labeled anti-glioma monoclonal antibody SZ-39 was injected intraperitoneally into nude mice bearing xenograft human glioma, ependymoma and intracranial metastatic adenocarcinoma. Subsequent gamma-imaging and assessment of radioactivity showed selective accumulation of antibody in the glioma. Quantitative autoradiography supported the results of radiolocalization observed in vivo in different brain tumors and normal tissues. It was also shown that antibody SZ-39 was specially localized to viable glioma cells and closely associated with their cell membrane. Yet, it was not bound to fibrous or necrotic areas. 131I-normal mouse IgG was distributed in a nonspecific pattern in the glioma. These studies demonstrated the specificity of SZ-39 in vivo which may be useful in clinical diagnostic guiding and treatment.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0253-3766
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
82-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Histologic distribution of anti-glioma monoclonal antibody SZ-39 in human xenograft brain tumors].
pubmed:affiliation
Neurologic Laboratory, Suzhou Medical College.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't