Linked Life Data

2805424

Source:http://linkedlifedata.com/resource/pubmed/id/2805424

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-12-15
pubmed:abstractText
The involvement of cellular immunity in alveolar echinococcosis (AE) due to E. multilocularis is strongly suggested by the intense granulomatous infiltration observed around the hepatic parasitic lesions, and a progressive decrease of specific cellular immunity has been described in murine AE. However, specific cellular immunity against E. multilocularis has never been documented in human AE. The reactivity to phytohaemagglutinin (PHA) and E. multilocularis antigens of peripheral blood mononuclear cells (PBMC) from 48 patients with AE and 35 control subjects was evaluated by incorporation of 3H-methylthymidine into DNA. A sequential measurement of the proliferative response of PBMC was performed in 20 patients 2 years later, and again in five of them 4 years after the first determination. After stimulation by PHA, the mean proliferation index (PI) of the patients with AE was somewhat higher than that observed in the uninfected controls, but the difference was not significant. The PI obtained with E. multilocularis antigens was higher than the threshold value in all the patients but one, and in five control subjects. The difference between the PI values in the patients with AE and those obtained in the control subjects was highly significant. There was no correlation between the lymphocyte proliferation indices and the specific antibodies assessed using the Em 2-ELISA, or the volume of the parasitic lesions. All the five 'positive' control subjects were living in areas endemic for AE. A previous contract of these subjects with E. multilocularis in the past, followed by a spontaneous elimination of the parasite is possible. The long-term persistence of lymphocyte reactivity to parasite antigens was emphasized by the results of the follow-up of 20 patients with AE: reactivity of PBMC decreased progressively but persisted more than 4 years after complete resection of the parasitic lesions in the patients who underwent a radical surgical procedure. Conversely, an increase in the PI was shown to be usually associated with a progression of the liver lesions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-1149867, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-2409507, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-2450418, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-2450708, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-3168321, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-3503416, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-3515794, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-3578654, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-4069754, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-431502, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-4914397, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-6192602, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-6382127, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-6510502, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-6741224, http://linkedlifedata.com/resource/pubmed/commentcorrection/2805424-729696
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Cellular immune response in Echinococcus multilocularis infection in humans. I. Lymphocyte reactivity to Echinococcus antigens in patients with alveolar echinococcosis.
pubmed:affiliation
Groupe de Recherche sur l'Echinococcose Alvéolaire (AREA) Faculté de Médecine, Besançon, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't