Linked Life Data

2805336

Source:http://linkedlifedata.com/resource/pubmed/id/2805336

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-12-19
pubmed:abstractText
In order to label postmitotic neuroblasts, pregnant mice received a single pulse of 5'-bromodeoxyuridine (BrdU) between embryonic days E11 and E17. Young adult offspring were stained for BrdU using a monoclonal antibody and the peroxidase-antiperoxidase method. The distribution of immunoreactive nuclei was very similar to the [3H]thymidine data reported in the literature. The pattern of labelled nuclei after injection at different embryonic ages followed the spatiotemporal gradients described for cortical and hippocampal neurogenesis. Lightly and heavily labelled nuclei, probably representing subsequent postmitotic generations, were distinguished in BrdU-immunoreacted preparations. These data indicate that BrdU can be used to map neuronal birthdates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Immunocytochemical detection of 5'-bromodeoxyuridine incorporation in the central nervous system of the mouse.
pubmed:affiliation
Unidad de Biología Celular, Facultad de Biología, Universidad de Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't