| pubmed-article:2805073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2805073 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2805073 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:2805073 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:2805073 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:2805073 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2805073 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:2805073 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2805073 | pubmed:dateCreated | 1989-12-7 | lld:pubmed |
| pubmed-article:2805073 | pubmed:abstractText | Human alloreactive T-cell clones derived from cells invading a rejected kidney allograft were found to be capable of proliferating upon specific antigenic stimulation in short term assays and in the absence of exogenous IL-2. In most culture supernatants there was no evidence of any activity capable of triggering proliferation of the murine IL-2-sensitive CTL-L2 line. The ability of these clones to produce IL-2 was investigated under several experimental conditions. A combination of phorbol ester plus calcium ionophore was very efficient in all clones tested (17/17) in inducing transcription of the IL-2 gene. Conversely, when cell activation took place through the CD3/Ti complex, we regularly failed to detect hu-IL-2 transcripts even when the number of stimulator cells was increased. However, a blockade of IL-2-R with a monoclonal antibody inhibiting ligand receptor interaction while decreasing proliferation induced by the antigen in dose-dependent fashion permitted the presence of IL-2 to be demonstrated in supernatants. These results strongly suggest that IL-2-driven proliferation is essential in this model and may represent a major, although not exclusive, pathway leading to proliferation of these clones. | lld:pubmed |
| pubmed-article:2805073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2805073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2805073 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2805073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2805073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2805073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2805073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2805073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2805073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2805073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2805073 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2805073 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:2805073 | pubmed:author | pubmed-author:PeyratM AMA | lld:pubmed |
| pubmed-article:2805073 | pubmed:author | pubmed-author:SoulillouJ... | lld:pubmed |
| pubmed-article:2805073 | pubmed:author | pubmed-author:MoreauJ FJF | lld:pubmed |
| pubmed-article:2805073 | pubmed:author | pubmed-author:MoisanJ PJP | lld:pubmed |
| pubmed-article:2805073 | pubmed:author | pubmed-author:HalletM MMM | lld:pubmed |
| pubmed-article:2805073 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2805073 | pubmed:volume | 124 | lld:pubmed |
| pubmed-article:2805073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2805073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2805073 | pubmed:pagination | 95-106 | lld:pubmed |
| pubmed-article:2805073 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:meshHeading | pubmed-meshheading:2805073-... | lld:pubmed |
| pubmed-article:2805073 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2805073 | pubmed:articleTitle | Proliferation dependence and production of IL-2 in human alloreactive T-cell clones. | lld:pubmed |
| pubmed-article:2805073 | pubmed:affiliation | INSERM U.211. Laboratorie d'Immunologie Clinique, Faculté de Médecine, Nantes, France. | lld:pubmed |
| pubmed-article:2805073 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2805073 | lld:pubmed |
