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pubmed-article:2804082pubmed:abstractTextThe phenomenon of an elevated copper concentration in melanoma tumors was examined. It was demonstrated that 50-60% of total tissue copper is associated with metallothionein. The amino acid composition, electronic absorption and fluorescence were identical to that of the many known vertebrate Cu-thioneins. The immunological identification of melanoma tissue metallothionein was successful. The elevated Cu-thionein concentration in melanoma tumor tissue is not yet understood. It appears to be a common concept that in most tumors transient changes of the copper status parallel the metallothionein levels.lld:pubmed
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pubmed-article:2804082pubmed:articleTitleCopper-thionein in melanoma.lld:pubmed
pubmed-article:2804082pubmed:affiliationAnorganische Biochemie, Physiologisch-Chemisches Institut der Universität Tübingen, F.R.G.lld:pubmed
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