rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1989-11-29
|
pubmed:abstractText |
The phenomenon of an elevated copper concentration in melanoma tumors was examined. It was demonstrated that 50-60% of total tissue copper is associated with metallothionein. The amino acid composition, electronic absorption and fluorescence were identical to that of the many known vertebrate Cu-thioneins. The immunological identification of melanoma tissue metallothionein was successful. The elevated Cu-thionein concentration in melanoma tumor tissue is not yet understood. It appears to be a common concept that in most tumors transient changes of the copper status parallel the metallothionein levels.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0006-3002
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
9
|
pubmed:volume |
1013
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
212-7
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2804082-Amino Acids,
pubmed-meshheading:2804082-Animals,
pubmed-meshheading:2804082-Chromatography, Gel,
pubmed-meshheading:2804082-Copper,
pubmed-meshheading:2804082-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2804082-Horses,
pubmed-meshheading:2804082-Humans,
pubmed-meshheading:2804082-Immunoblotting,
pubmed-meshheading:2804082-Liver,
pubmed-meshheading:2804082-Melanoma,
pubmed-meshheading:2804082-Mercaptoethanol,
pubmed-meshheading:2804082-Metallothionein,
pubmed-meshheading:2804082-Mice,
pubmed-meshheading:2804082-Mice, Inbred BALB C,
pubmed-meshheading:2804082-Rats,
pubmed-meshheading:2804082-Spectrophotometry
|
pubmed:year |
1989
|
pubmed:articleTitle |
Copper-thionein in melanoma.
|
pubmed:affiliation |
Anorganische Biochemie, Physiologisch-Chemisches Institut der Universität Tübingen, F.R.G.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|