Linked Life Data

2803857

Source:http://linkedlifedata.com/resource/pubmed/id/2803857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-12-18
pubmed:abstractText
Studies demonstrate that geometric changes in bone architecture in response to altered mechanical strain occur through the formation of woven bone. The goal of this study was to test the hypothesis that these changes are partly the result of surgical manipulation rather than a true adaptive response to altered strain. Beagle dogs were subjected to either an ulnar osteotomy, an osteotomy with plate fixation, or sham operation. Strains on the radius were measured just prior to sacrifice 1, 3 or 6 months after surgery. Our results support the idea that woven bone can be a normal response to an abnormal strain environment if the mechanical challenge is intense enough; that elevated mechanical strains can cause the endocortical bone envelope to revert to a state of net formation; and that "adaptive remodeling" in adults in response to a change in mechanical strain may be a special case of modeling in which resorption is not required prior to formation at a particular skeletal site.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
8756-3282
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-33
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Skeletal change in response to altered strain environments: is woven bone a response to elevated strain?
pubmed:affiliation
Department of Anatomy, West Virginia University, Morgantown.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't