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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-11-20
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pubmed:abstractText |
20 KDa homologous restriction factor (HRF20) is a membrane glycoprotein which inhibits formation of membrane attack complexes of homologous complement. Erythrocytes from a patient who is completely deficient in HRF20 were readily hemolyzed by homologous complement activated by sucrose or by acidification as in paroxysmal nocturnal hemoglobinuria (PNH). After incubating PNH erythrocytes (PNH-E) with purified HRF20, the cells were analyzed by flow cytometry using a monoclonal antibody to HRF20 and shown to have the antigen absorbed. These PNH-E acquired resistance to hemolysis by homologous complement suggesting that HRF20 may be successfully used for treatment of these patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
468-73
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pubmed:dateRevised |
2006-4-15
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pubmed:meshHeading |
pubmed-meshheading:2803313-Adult,
pubmed-meshheading:2803313-Antigens, CD59,
pubmed-meshheading:2803313-Blood Proteins,
pubmed-meshheading:2803313-Carrier Proteins,
pubmed-meshheading:2803313-Erythrocytes,
pubmed-meshheading:2803313-Flow Cytometry,
pubmed-meshheading:2803313-Hemoglobinuria, Paroxysmal,
pubmed-meshheading:2803313-Hemolysis,
pubmed-meshheading:2803313-Humans,
pubmed-meshheading:2803313-Male,
pubmed-meshheading:2803313-Membrane Glycoproteins,
pubmed-meshheading:2803313-Molecular Weight
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pubmed:year |
1989
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pubmed:articleTitle |
Complete deficiency of 20 KDa homologous restriction factor (HRF20) and restoration with purified HRF20.
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pubmed:affiliation |
Department of Microbiology, Fukuoka University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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