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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-11-8
|
| pubmed:abstractText |
To estimate the replication of the human T-cell leukemia virus type I (HTLV-I) in patients with HTLV-I-associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV-I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV-I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymptomatic carriers. Therefore, HAM/TSP development is associated with a high level of HTLV-I replication. In addition, lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV-I DNA, indicating adult T-cell leukemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0364-5134
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
331-5
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2802532-Adult,
pubmed-meshheading:2802532-DNA Replication,
pubmed-meshheading:2802532-Female,
pubmed-meshheading:2802532-Humans,
pubmed-meshheading:2802532-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:2802532-Middle Aged,
pubmed-meshheading:2802532-Muscular Diseases,
pubmed-meshheading:2802532-Nucleic Acid Hybridization,
pubmed-meshheading:2802532-Paraparesis, Tropical Spastic,
pubmed-meshheading:2802532-Virus Replication
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Increased replication of HTLV-I in HTLV-I-associated myelopathy.
|
| pubmed:affiliation |
Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|