Linked Life Data

2801585

Source:http://linkedlifedata.com/resource/pubmed/id/2801585

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-11-3
pubmed:abstractText
Branched-chain ketoacids (BCKAs) were determined in fasting plasma samples from 19 patients with chronic renal failure (CRF). Ketomethylvalerate (KMV) was significantly higher in patients receiving BCKA supplements, presumably reflecting accumulation of the R(-) isomer. Mean levels of all three BCKAs were not significantly different from normal. However, multiple-regression analysis showed that plasma ketoisocaproate was strongly correlated with glomerular filtration rate (GFR), negatively correlated with serum triglyceride concentration, and positively correlated with protein intake. KMV concentration was also correlated positively with GFR, negatively with triglyceridemia, and positively with serum total carbon dioxide. Ketoisovalerate concentration did not vary with GFR and was not predictable from the regressors used. Single oral doses of a mixture containing all three BCKAs led to the same areas under the three plasma concentration curves in patients with CRF as in normal subjects, indicating that absorption of all three BCKAs after oral administration in patients with CRF is unimpaired.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0002-9165
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
807-13
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Branched-chain-ketoacid metabolism in patients with chronic renal failure.
pubmed:affiliation
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.