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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1989-11-7
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pubmed:abstractText |
Adenovirus 2 virions contain a small, highly basic protein known as mu (mu). Partial sequence analysis of mu labeled with radioactive amino acids showed that it is derived from an 11-kDa virion precursor protein, L2-79R. Amino acid analysis, direct microsequence analysis, time-of-flight mass spectrometer analysis, and chemical synthesis demonstrated that mu is the unmodified, 19 amino acid peptide obtained from the 79-residue precursor by adenovirus-encoded proteinase-mediated cleavage after glycine31 and glycine50. Mu bound tightly to DNA and was located in the virion core. In vitro, mu could precipitate DNA fragments, suggesting that it may have a role in viral chromosome condensation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0042-6822
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
506-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2800334-Adenoviruses, Human,
pubmed-meshheading:2800334-Amino Acid Sequence,
pubmed-meshheading:2800334-Amino Acids,
pubmed-meshheading:2800334-Centrifugation, Density Gradient,
pubmed-meshheading:2800334-Chromatography, High Pressure Liquid,
pubmed-meshheading:2800334-Chromatography, Ion Exchange,
pubmed-meshheading:2800334-DNA-Binding Proteins,
pubmed-meshheading:2800334-Electrophoresis, Agar Gel,
pubmed-meshheading:2800334-HeLa Cells,
pubmed-meshheading:2800334-Humans,
pubmed-meshheading:2800334-Molecular Sequence Data,
pubmed-meshheading:2800334-Protein Precursors,
pubmed-meshheading:2800334-Viral Core Proteins,
pubmed-meshheading:2800334-Virion
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pubmed:year |
1989
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pubmed:articleTitle |
Characterization of the adenovirus 2 virion protein, mu.
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pubmed:affiliation |
Biology Department, Brookhaven National Laboratory, Upton, New York 11973.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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