| pubmed-article:279911 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:279911 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:279911 | lifeskim:mentions | umls-concept:C0016006 | lld:lifeskim |
| pubmed-article:279911 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:279911 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:279911 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:279911 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:279911 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:279911 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:279911 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:279911 | pubmed:dateCreated | 1978-12-27 | lld:pubmed |
| pubmed-article:279911 | pubmed:abstractText | Fibrinogen displays a regulation of considerable physiological significance by lowering the Ca2+ requirement for the conversion of the fibrin-stabilizing factor (Factor XIII) zymogen to the range of concentrations of this ion found in plasma. Fibrinogen modulates both Ca2+-dependent steps in the complex process of zymogen activation, involving the heterologous dissociation of subunits of the thrombin-modified zymogen (Factor XIII') species : formula: (see text) and the unmasking of iodoacetamide titratable sites during generation of transamidating activity : formula: (see text). It is interesting that a thrombin-independent pathway of zymogen activation : formula: (see text), which we found to operate at Ca2+ concentrations above 50 mM, is not affected by the presence of fibrinogen. Regulation by fibrinogen thus appears to be specific for controlling only the physiological pathway of zymogen conversion. | lld:pubmed |
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| pubmed-article:279911 | pubmed:language | eng | lld:pubmed |
| pubmed-article:279911 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:279911 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:279911 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:279911 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:279911 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:279911 | pubmed:author | pubmed-author:LorandLL | lld:pubmed |
| pubmed-article:279911 | pubmed:author | pubmed-author:CredoR BRB | lld:pubmed |
| pubmed-article:279911 | pubmed:author | pubmed-author:CurtisC GCG | lld:pubmed |
| pubmed-article:279911 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:279911 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:279911 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:279911 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:279911 | pubmed:pagination | 4234-7 | lld:pubmed |
| pubmed-article:279911 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:279911 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:279911 | pubmed:articleTitle | Ca2+-related regulatory function of fibrinogen. | lld:pubmed |
| pubmed-article:279911 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:279911 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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