|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1978-12-27
|
|
pubmed:abstractText |
Fibrinogen displays a regulation of considerable physiological significance by lowering the Ca2+ requirement for the conversion of the fibrin-stabilizing factor (Factor XIII) zymogen to the range of concentrations of this ion found in plasma. Fibrinogen modulates both Ca2+-dependent steps in the complex process of zymogen activation, involving the heterologous dissociation of subunits of the thrombin-modified zymogen (Factor XIII') species : formula: (see text) and the unmasking of iodoacetamide titratable sites during generation of transamidating activity : formula: (see text). It is interesting that a thrombin-independent pathway of zymogen activation : formula: (see text), which we found to operate at Ca2+ concentrations above 50 mM, is not affected by the presence of fibrinogen. Regulation by fibrinogen thus appears to be specific for controlling only the physiological pathway of zymogen conversion.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-1011990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-1111094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-13018207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-13032161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-14165504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-14843145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-197955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-197956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-201628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4133182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4149557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4239491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4365089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4405643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4455208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4463957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4565370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4736472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4778285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4811064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4831071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-4859234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-5096097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-5260927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-5550151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-5761215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/279911-796625
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
75
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4234-7
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1978
|
|
pubmed:articleTitle |
Ca2+-related regulatory function of fibrinogen.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
