Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1989-11-21
|
| pubmed:abstractText |
The bone-marrow microenvironment has a decisive role in maintaining haemopoietic stem cells and regulating their differentiation. In diseases of the haemopoietic system, viz. anaemias and leukemias, the microenvironment has been shown to play a key role. In this paper we show that leukemic cell conditioned medium and sera from CML patients, interact with the in vitro bone-marrow environment and bring about changes which affect the maintenance of normal stem cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0145-2126
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
811-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2796386-Animals,
pubmed-meshheading:2796386-Bone Marrow,
pubmed-meshheading:2796386-Cell Adhesion,
pubmed-meshheading:2796386-Cell Division,
pubmed-meshheading:2796386-Colony-Forming Units Assay,
pubmed-meshheading:2796386-Hematopoiesis,
pubmed-meshheading:2796386-Hematopoietic Stem Cells,
pubmed-meshheading:2796386-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:2796386-Mice,
pubmed-meshheading:2796386-Time Factors,
pubmed-meshheading:2796386-Tumor Cells, Cultured
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Disruption of stromal niches by diffusible factors in the conditioned media of leukemic cell-lines and sera of chronic myelogenous leukemia patients.
|
| pubmed:affiliation |
Cell Biology Division, Tata Memorial Centre, Bombay, India.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|