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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
1989-11-7
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pubmed:abstractText |
Spirogermanium was given as a 90 minute infusion to 47 eligible patients with refractory Hodgkin's (9 patients) or non-Hodgkin's lymphoma (38 patients). The schedule was 80 mg/m2 three times a week for the first two weeks and 100 mg/m2, 3 times a week, for the two subsequent weeks. In case of response or stable disease, the treatment was continued with biweekly infusions of 100 mg/m2 until tumor progression. In 64% of cases, three or more combinations had been previously administered; 66% of patients presented an extra-lymphatic spread of disease. Two patients with Hodgkin's disease showed a partial response of 11 and 23 weeks and two patients with non-Hodgkin's lymphoma achieved a complete response of 12 and 24 weeks. Overall, 14 patients showed a tumor progression within the first month of treatment. The main toxicity was neurological, with dizziness and lethargy during the infusion in 50% of cases. Hematologic toxicity was almost absent. Spirogermanium is ineffective in heavily pretreated patients with non-Hodgkin's lymphoma. The confirmed lack of activity in patients with refractory malignant lymphoma and the need of repeated and prolonged infusions definitely discourage the clinical use of the drug.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0167-6997
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-22
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2793376-Adult,
pubmed-meshheading:2793376-Aged,
pubmed-meshheading:2793376-Antineoplastic Agents,
pubmed-meshheading:2793376-Drug Evaluation,
pubmed-meshheading:2793376-Female,
pubmed-meshheading:2793376-Hodgkin Disease,
pubmed-meshheading:2793376-Humans,
pubmed-meshheading:2793376-Lymphoma,
pubmed-meshheading:2793376-Lymphoma, Non-Hodgkin,
pubmed-meshheading:2793376-Male,
pubmed-meshheading:2793376-Middle Aged,
pubmed-meshheading:2793376-Organometallic Compounds,
pubmed-meshheading:2793376-Spiro Compounds
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pubmed:year |
1989
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pubmed:articleTitle |
A phase II study of spirogermanium in patients with advanced malignant lymphoma.
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pubmed:affiliation |
Servizio Oncologico, Ospedale San Giovanni, Bellinzona, Switzerland.
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pubmed:publicationType |
Journal Article
|