Linked Life Data

2792190

Source:http://linkedlifedata.com/resource/pubmed/id/2792190

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-11-6
pubmed:abstractText
The number of prolactin (PRL) receptors in the hypothalamus and substantia nigra of aged rabbits is significantly lower than the number measured in young animals. The treatment of aged rabbits for 30 days with S-adenosyl-L-methionine (SAM) restored the number of PRL binding sites to levels found in the hypothalamus and substantia nigra from young animals. We did not observe a clear-cut difference between the dissociation constants of untreated young, and untreated or SAM-treated aged rabbits, whereas the binding capacity varied. Moreover, in vitro addition of SAM to hypothalamic membranes from aged rabbits resulted in a significant increase in the number of binding sites. This in vitro effect was antagonized by S-adenosyl-L-homocysteine, a specific in vitro inhibitor of methyltransferase activity. The reduction in the number of PRL receptors is assumed to be related to the decrease in membrane fluidity induced by aging, while its increase after SAM treatment might be ascribed to the ability of this methyl donor to increase the fluidity of cell membranes by stimulating phospholipid synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
166
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-30
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
S-adenosyl-L-methionine restores prolactin receptors in the aged rabbit brain.
pubmed:affiliation
Institute of Pharmacology, University of Turin, Italy.
pubmed:publicationType
Journal Article