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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-11-15
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pubmed:abstractText |
The internalization of surface immunoglobulin (Ig) by B lymphocytes is the first step in the antigen-presenting function performed by these cells. Mature B cells coexpress on their surface IgM and IgD. At this time, there is controversy over whether these two isotypes serve different functions in the antigen-presenting process. The results presented here show that the intracellular pattern of distribution of IgM and IgD after internalization is strikingly different in the B cell lines studied. These findings support the hypothesis that the role of the two Ig classes in the antigen-presenting function may be different.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-8749
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
456-61
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2790970-Animals,
pubmed-meshheading:2790970-B-Lymphocytes,
pubmed-meshheading:2790970-Cell Line,
pubmed-meshheading:2790970-Cross-Linking Reagents,
pubmed-meshheading:2790970-Endocytosis,
pubmed-meshheading:2790970-Immunoglobulin D,
pubmed-meshheading:2790970-Immunoglobulin M,
pubmed-meshheading:2790970-Membrane Proteins,
pubmed-meshheading:2790970-Mice,
pubmed-meshheading:2790970-Receptors, Antigen, B-Cell
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pubmed:year |
1989
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pubmed:articleTitle |
Differential endocytosis of IgM and IgD in murine B cell lines.
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pubmed:affiliation |
Division of Pediatric Hematology-Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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