Linked Life Data

2790333

Source:http://linkedlifedata.com/resource/pubmed/id/2790333

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-11-3
pubmed:abstractText
We previously described an exponential correlation of the CFU-GM content of 4-hydroperoxycyclophosphamide-treated autologous bone marrow grafts and the rate of hematologic recovery of the recipients after transplantation. Those grafts were assayed before cryopreservation. We now describe a similar analysis based upon cultures of the thawed bone marrow. In a proportional hazards model, the CFU-GM content of the grafts sampled after thawing predicted time to achieving a peripheral blood count of 1 X 10(9)/l leukocytes, 0.5 X 10(9)/l granulocytes, 2% reticulocytes, and last platelet transfusion (p less than 0.001). Using linear regression analysis, the logarithm of the CFU-GM content/kg of recipient weight also was correlated with the time to achieving 1 X 10(9)/l leukocytes (r = -0.62), and 0.5 X 10(9)/l granulocytes (r = -0.66). The hazard ratios (Cox model) and regression coefficients (linear regression model) for the equations calculated from the post-thaw cultures were usually smaller than the corresponding coefficients based upon the pre-freeze cultures, suggesting that pre-freeze cultures may be more accurate predictors of aplasia duration. However, patients with poor post-freeze survival of CFU-GM were more likely to experience delayed engraftment. Therefore, the correlation of post-thaw cultures with engraftment may permit the analysis of cryopreservation techniques.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0268-3369
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
553-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Correlation of hematologic recovery with CFU-GM content of autologous bone marrow grafts treated with 4-hydroperoxycyclophosphamide. Culture after cryopreservation.
pubmed:affiliation
Johns Hopkins Oncology Center, Baltimore, MD 21205.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.