| pubmed-article:2789331 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C1706515 | lld:lifeskim |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C1704640 | lld:lifeskim |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:2789331 | lifeskim:mentions | umls-concept:C0331858 | lld:lifeskim |
| pubmed-article:2789331 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2789331 | pubmed:dateCreated | 1989-10-23 | lld:pubmed |
| pubmed-article:2789331 | pubmed:abstractText | Effect of reconstituted type I collagen gel on in vitro growth of fibroblasts was examined. A prolonged lag period was observed by culture either on the surface of three-dimensional collagen gel ("on-gel") or within the gels ("in-gel") as compared with the culture on plastic dishes. The rate of cell proliferation in logarithmic phase growth was repressed by the culture "in-gel" but not by the culture "on-gel". The differential growth rates between "in-gel" culture and "on-gel" culture should be ascribed to difference in distributions of interacting sites between cell and collagen fibrils. The repression of cell growth was more marked in a contracting collagen gel which contains higher density of collagen fibrils. The cell density in contracted gel per unit cross-section area was found to be much lower than that of confluent monolayer culture. These results suggest that the repression of cell growth by collagen fibrils in the three-dimensional gels is not due to direct cell-cell contact, but due to the distribution and number of contact sites between a cell and collagen fibrils. | lld:pubmed |
| pubmed-article:2789331 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2789331 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2789331 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2789331 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2789331 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2789331 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2789331 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2789331 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2789331 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2789331 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2789331 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2789331 | pubmed:issn | 0934-8832 | lld:pubmed |
| pubmed-article:2789331 | pubmed:author | pubmed-author:HayashiTT | lld:pubmed |
| pubmed-article:2789331 | pubmed:author | pubmed-author:NakayamaYY | lld:pubmed |
| pubmed-article:2789331 | pubmed:author | pubmed-author:NishiyamaTT | lld:pubmed |
| pubmed-article:2789331 | pubmed:author | pubmed-author:AdachiEE | lld:pubmed |
| pubmed-article:2789331 | pubmed:author | pubmed-author:TsunenagaMM | lld:pubmed |
| pubmed-article:2789331 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2789331 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:2789331 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2789331 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2789331 | pubmed:pagination | 193-9 | lld:pubmed |
| pubmed-article:2789331 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2789331 | pubmed:meshHeading | pubmed-meshheading:2789331-... | lld:pubmed |
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| pubmed-article:2789331 | pubmed:meshHeading | pubmed-meshheading:2789331-... | lld:pubmed |
| pubmed-article:2789331 | pubmed:meshHeading | pubmed-meshheading:2789331-... | lld:pubmed |
| pubmed-article:2789331 | pubmed:meshHeading | pubmed-meshheading:2789331-... | lld:pubmed |
| pubmed-article:2789331 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2789331 | pubmed:articleTitle | Growth rate of human fibroblasts is repressed by the culture within reconstituted collagen matrix but not by the culture on the matrix. | lld:pubmed |
| pubmed-article:2789331 | pubmed:affiliation | Shiseido Basic Research Laboratories, Yokohama, Japan. | lld:pubmed |
| pubmed-article:2789331 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2789331 | lld:pubmed |
