| pubmed-article:2788515 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2788515 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:2788515 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:2788515 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:2788515 | lifeskim:mentions | umls-concept:C0558295 | lld:lifeskim |
| pubmed-article:2788515 | lifeskim:mentions | umls-concept:C0017263 | lld:lifeskim |
| pubmed-article:2788515 | lifeskim:mentions | umls-concept:C0018591 | lld:lifeskim |
| pubmed-article:2788515 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2788515 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2788515 | pubmed:dateCreated | 1989-9-28 | lld:pubmed |
| pubmed-article:2788515 | pubmed:abstractText | The lymphocytic choriomeningitis virus (LCMV)-specific Tc response in (C3 X D2) F1 hybrids (k X d) is markedly biased in favor of the H-2d haplotype. Adoptive transfer experiments established that this haplotype preference also applied to T cell function in vivo. Using different mouse strain combinations we were unable to detect an influence of sex, non-H-2 background, maternal genotype, or route of priming on the preference pattern. In other haplotype combinations tested (k and b, b and d) no distinct haplotype preference was observed. A comparison of the LCMV-specific Tc response of (C X C3) F1 and (C-H-2dm2 X C3) F1 hybrids revealed that the dominance of the H-2d haplotype was controlled by H-2Ld. The ability of this gene to down-regulate the generation of an H-2k-restricted response did not seem to reflect antigenic mimicry since H-2k-restricted LCMV-specific Tc did not lyse H-2d expressing targets. In regard to the in vivo significance of haplotype preference it was found that (C X C3) F1 mice expressed an earlier and stronger virus-specific delayed type hypersensitivity response and exerted a more efficient virus control than did (C-H-2dm2 X C3) F1. Taken together these findings suggest that haplotype preference reflects a selection process favoring the restriction element associated with the most efficient immune response in vivo. The implications of this are discussed. | lld:pubmed |
| pubmed-article:2788515 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2788515 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2788515 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2788515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2788515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2788515 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2788515 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2788515 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:2788515 | pubmed:author | pubmed-author:MarkerOO | lld:pubmed |
| pubmed-article:2788515 | pubmed:author | pubmed-author:ThomsenA RAR | lld:pubmed |
| pubmed-article:2788515 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2788515 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:2788515 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2788515 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2788515 | pubmed:pagination | 365-76 | lld:pubmed |
| pubmed-article:2788515 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:meshHeading | pubmed-meshheading:2788515-... | lld:pubmed |
| pubmed-article:2788515 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2788515 | pubmed:articleTitle | Class I gene regulation of haplotype preference may influence antiviral immunity in vivo. | lld:pubmed |
| pubmed-article:2788515 | pubmed:affiliation | Institute of Medical Microbiology, University of Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:2788515 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2788515 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2788515 | lld:pubmed |
