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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-9-28
|
| pubmed:abstractText |
The lymphocytic choriomeningitis virus (LCMV)-specific Tc response in (C3 X D2) F1 hybrids (k X d) is markedly biased in favor of the H-2d haplotype. Adoptive transfer experiments established that this haplotype preference also applied to T cell function in vivo. Using different mouse strain combinations we were unable to detect an influence of sex, non-H-2 background, maternal genotype, or route of priming on the preference pattern. In other haplotype combinations tested (k and b, b and d) no distinct haplotype preference was observed. A comparison of the LCMV-specific Tc response of (C X C3) F1 and (C-H-2dm2 X C3) F1 hybrids revealed that the dominance of the H-2d haplotype was controlled by H-2Ld. The ability of this gene to down-regulate the generation of an H-2k-restricted response did not seem to reflect antigenic mimicry since H-2k-restricted LCMV-specific Tc did not lyse H-2d expressing targets. In regard to the in vivo significance of haplotype preference it was found that (C X C3) F1 mice expressed an earlier and stronger virus-specific delayed type hypersensitivity response and exerted a more efficient virus control than did (C-H-2dm2 X C3) F1. Taken together these findings suggest that haplotype preference reflects a selection process favoring the restriction element associated with the most efficient immune response in vivo. The implications of this are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0008-8749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
122
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
365-76
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2788515-Animals,
pubmed-meshheading:2788515-Antigens, Viral,
pubmed-meshheading:2788515-Cytotoxicity, Immunologic,
pubmed-meshheading:2788515-Genetic Variation,
pubmed-meshheading:2788515-H-2 Antigens,
pubmed-meshheading:2788515-Haplotypes,
pubmed-meshheading:2788515-Hypersensitivity, Delayed,
pubmed-meshheading:2788515-Immunity, Cellular,
pubmed-meshheading:2788515-Lymphocytic choriomeningitis virus,
pubmed-meshheading:2788515-Major Histocompatibility Complex,
pubmed-meshheading:2788515-Mice,
pubmed-meshheading:2788515-Spleen,
pubmed-meshheading:2788515-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Class I gene regulation of haplotype preference may influence antiviral immunity in vivo.
|
| pubmed:affiliation |
Institute of Medical Microbiology, University of Copenhagen, Denmark.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|