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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1989-9-12
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pubmed:abstractText |
The potential of the hepadnavirus X gene product to activate gene expression in trans was tested through a series of cotransfections of X expression vectors with a variety of potential targets for transactivation. The X gene products from human hepatitis B virus (HBV), woodchuck hepatitis virus, and ground squirrel hepatitis virus are all equally active in augmenting the expression of a wide array of target promoters in both permissive and nonpermissive cells. Using the HBV genome itself as the source of X protein, we demonstrate that transactivation of HBV and heterologous genes occurs when X protein is expressed in its native state during productive infection of permissive cells. Run-on transcription analysis indicates that this transactivation occurs at the level of primary transcription.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-1228224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-2427746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-2822953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-2826805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-2832251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-2841501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-2847409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-2948653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-2981434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3019565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3025872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3028247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3033659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3039907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3186723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3261866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3494193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3494252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3510311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-364941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3891326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-3926485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-399329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-6195530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-6326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-6960240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788226-7041126
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4019-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2788226-Genes, Viral,
pubmed-meshheading:2788226-Hepatitis B virus,
pubmed-meshheading:2788226-Promoter Regions, Genetic,
pubmed-meshheading:2788226-RNA, Messenger,
pubmed-meshheading:2788226-RNA, Viral,
pubmed-meshheading:2788226-Transcription, Genetic,
pubmed-meshheading:2788226-Viral Proteins,
pubmed-meshheading:2788226-Virus Replication
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pubmed:year |
1989
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pubmed:articleTitle |
Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication.
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pubmed:affiliation |
Department of Biochemistry and Biophysics, University of California Medical Center, San Francisco 94143-0502.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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