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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-9-7
|
| pubmed:abstractText |
Interleukin-6 (IL-6) was found to be a growth factor of renal cell carcinomas Furthermore, renal cell carcinomas freshly isolated from the patients expressed mRNA of IL-6 and secreted biologically active IL-6 under the culture conditions where the tumor cells could grow, but they did not produce IL-6 nor proliferate in the absence of fetal calf serum. The production of IL-6 by the tumor cells was also demonstrated by immunostaining of the IL-6-producing cells utilizing anti-IL-6 antiserum. Moreover, anti-IL-6 antiserum specifically inhibited the in vitro tumor growth. All data indicated that IL-6 functions as an in vitro autocrine growth factor of renal cell carcinomas.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
250
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
607-10
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2787758-Blotting, Northern,
pubmed-meshheading:2787758-Carcinoma, Renal Cell,
pubmed-meshheading:2787758-Growth Substances,
pubmed-meshheading:2787758-Humans,
pubmed-meshheading:2787758-Interleukin-6,
pubmed-meshheading:2787758-Interleukins,
pubmed-meshheading:2787758-Kidney Neoplasms,
pubmed-meshheading:2787758-RNA, Messenger
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas.
|
| pubmed:affiliation |
Third Department of Internal Medicine, Nissei Hospital, Osaka, Japan.
|
| pubmed:publicationType |
Journal Article
|