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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-9-1
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pubmed:abstractText |
An important unanswered question in clinical immunology is why the histocompatibility antigens HLA-B8/DR3 should be associated with at least nine quite different immune-mediated diseases. The purpose of this study was to examine the mechanism of an immunologic abnormality, commonly found in healthy individuals with HLA-DR3, that may reflect an immune defect predisposing to autoimmunity. Fourteen healthy subjects with HLA-DR3 had a proliferative response to a suboptimal concentration of PHA nearly eight-fold lower than that observed in 10 individuals without this HLA antigen. Impaired responsiveness to PHA was more strongly associated with HLA-DR3 than with HLA-B8. The IL-2 concentration in mitogen-stimulated cultures was similarly decreased in subjects with HLA-DR3 and was highly predictive of the proliferative response 24 h later (r = 0.82, P less than 0.0001). Inhibition of IL-2 utilization by anti-IL-2 receptor antibody indicated that the reduced IL-2 concentration reflects impaired lymphokine production rather than increased utilization. Expression of IL-2 receptors is decreased in these subjects, although the magnitude of their proliferative response is appropriate for the available lymphokine. These results indicate that impaired lymphocyte activation associated with HLA-DR3 reflects impaired IL-2 production and an abnormality of activation events preceding the production of this lymphokine.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-132279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2411790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2417308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2443540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2871336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2936862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2953803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2955975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2987968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-2997088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-307029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-313849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-3262468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-3485020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-3500214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-3874077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-46646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-6092510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-6213340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-6222112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-6408186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-6636110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-6969363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-6970774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-6980966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787712-75690
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
317-23
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2787712-Adult,
pubmed-meshheading:2787712-Cells, Cultured,
pubmed-meshheading:2787712-Dose-Response Relationship, Immunologic,
pubmed-meshheading:2787712-Female,
pubmed-meshheading:2787712-HLA-B Antigens,
pubmed-meshheading:2787712-HLA-B8 Antigen,
pubmed-meshheading:2787712-HLA-DR Antigens,
pubmed-meshheading:2787712-HLA-DR3 Antigen,
pubmed-meshheading:2787712-Humans,
pubmed-meshheading:2787712-Interleukin-2,
pubmed-meshheading:2787712-Lymphocyte Activation,
pubmed-meshheading:2787712-Male,
pubmed-meshheading:2787712-Middle Aged,
pubmed-meshheading:2787712-Phenotype,
pubmed-meshheading:2787712-Phytohemagglutinins,
pubmed-meshheading:2787712-Receptors, Interleukin-2,
pubmed-meshheading:2787712-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
Mechanism of a lymphocyte abnormality associated with HLA-B8/DR3 in clinically healthy individuals.
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pubmed:affiliation |
Department of Medicine, Louisiana State University Medical Center, New Orleans.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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