| pubmed-article:2787530 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2787530 | lifeskim:mentions | umls-concept:C1326205 | lld:lifeskim |
| pubmed-article:2787530 | lifeskim:mentions | umls-concept:C1718423 | lld:lifeskim |
| pubmed-article:2787530 | pubmed:issue | 4915 | lld:pubmed |
| pubmed-article:2787530 | pubmed:dateCreated | 1989-8-18 | lld:pubmed |
| pubmed-article:2787530 | pubmed:abstractText | To characterize cell surface molecules involved in control of growth of malignant lymphocytes, monoclonal antibodies were raised against the human B lymphoblast cell line SKW6.4. One monoclonal antibody, anti-APO-1, reacted with a 52-kilodalton antigen (APO-1) on a set of activated human lymphocytes, on malignant human lymphocyte lines, and on some patient-derived leukemic cells. Nanogram quantities of anti-APO-1 completely blocked proliferation of cells bearing APO-1 in vitro in a manner characteristic of a process called programmed cell death or apoptosis. Cell death was preceded by changes in cell morphology and fragmentation of DNA. This process was distinct from antibody- and complement-dependent cell lysis and was mediated by the antibody alone. A single intravenous injection of anti-APO-1 into nu/nu mice carrying a xenotransplant of a human B cell tumor induced regression of this tumor within a few days. Histological thin sections of the regressing tumor showed that anti-APO-1 was able to induce apoptosis in vivo. Thus, induction of apoptosis as a consequence of a signal mediated through cell surface molecules like APO-1 may be a useful therapeutic approach in treatment of malignancy. | lld:pubmed |
| pubmed-article:2787530 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2787530 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2787530 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2787530 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2787530 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2787530 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:2787530 | pubmed:author | pubmed-author:KrammerP HPH | lld:pubmed |
| pubmed-article:2787530 | pubmed:author | pubmed-author:MatzkuSS | lld:pubmed |
| pubmed-article:2787530 | pubmed:author | pubmed-author:PetersA MAM | lld:pubmed |
| pubmed-article:2787530 | pubmed:author | pubmed-author:FalkWW | lld:pubmed |
| pubmed-article:2787530 | pubmed:author | pubmed-author:MöllerPP | lld:pubmed |
| pubmed-article:2787530 | pubmed:author | pubmed-author:KNOPC QCQ | lld:pubmed |
| pubmed-article:2787530 | pubmed:author | pubmed-author:TrauthB CBC | lld:pubmed |
| pubmed-article:2787530 | pubmed:author | pubmed-author:DebatinK MKM | lld:pubmed |
| pubmed-article:2787530 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2787530 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:2787530 | pubmed:volume | 245 | lld:pubmed |
| pubmed-article:2787530 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2787530 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2787530 | pubmed:pagination | 301-5 | lld:pubmed |
| pubmed-article:2787530 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:2787530 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2787530 | pubmed:articleTitle | Monoclonal antibody-mediated tumor regression by induction of apoptosis. | lld:pubmed |
| pubmed-article:2787530 | pubmed:affiliation | Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg. | lld:pubmed |
| pubmed-article:2787530 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2787530 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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