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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-8-11
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pubmed:abstractText |
The role of IL-7 in the stromal cell-dependent B cell development was investigated using two stromal cell clones, ST2 and PA6; the former supports B lymphopoiesis while the latter can not. We demonstrate here that: (a) the ability of the stromal cell clone to produce IL-7 correlates well with the stromal cell activity to support B lymphopoiesis; (b) IL-7 production by ST2 is inducible rather than constitutive; (c) the IL-7-dependent B cell itself is a potent inducer of IL-7 production by ST2; (d) addition of rIL-7 to the PA6 layer renders this in vitro environment B lymphopoietic; and (e) the differentiation from early B progenitor to pre-B cell requires both IL-7 and other stromal cell molecule(s) yet to be identified.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-2823259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-2825196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-2868799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-2965020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-3258354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-3259677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-3261687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-3264531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-3276783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-3318292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-3493849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-6167630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-6984001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-7107718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2787384-89034
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
333-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2787384-Animals,
pubmed-meshheading:2787384-B-Lymphocytes,
pubmed-meshheading:2787384-Base Sequence,
pubmed-meshheading:2787384-Cell Line,
pubmed-meshheading:2787384-Cells, Cultured,
pubmed-meshheading:2787384-Clone Cells,
pubmed-meshheading:2787384-DNA Probes,
pubmed-meshheading:2787384-Genes,
pubmed-meshheading:2787384-Interleukin-7,
pubmed-meshheading:2787384-Interleukins,
pubmed-meshheading:2787384-Mice,
pubmed-meshheading:2787384-Molecular Sequence Data,
pubmed-meshheading:2787384-RNA, Messenger,
pubmed-meshheading:2787384-Recombinant Proteins,
pubmed-meshheading:2787384-Restriction Mapping,
pubmed-meshheading:2787384-Transcription, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
Interleukin 7 production and function in stromal cell-dependent B cell development.
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pubmed:affiliation |
Biomaterial Research Institute Co. Ltd., Yokohama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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