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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0021758,
umls-concept:C0040649,
umls-concept:C0205147,
umls-concept:C0205263,
umls-concept:C0439831,
umls-concept:C0591833,
umls-concept:C1552644,
umls-concept:C1707719,
umls-concept:C1823153,
umls-concept:C1879547,
umls-concept:C2349976
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pubmed:issue |
2
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pubmed:dateCreated |
1989-6-29
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pubmed:abstractText |
The distribution of immunoglobulin isotypes in activated B lymphocytes can be modulated by interleukin 4 (IL4), which enhances IgG1 and suppresses IgG3. We show here that IL4 induces transcription of the region 5' adjacent to the s gamma 1 switch region within hours after onset of activation of B cells by bacterial lipopolysaccharide (LPS). Transcripts of 1.7 and 3.2 kb size containing sequences of the region 5' of s gamma 1 are detected. This transcription precedes class switch recombination between s mu and s gamma 1 and reflects the rapid opening of the s gamma 1 region as induced by IL4. This suggests that IL4 directs class switching to IgG1 by opening the s gamma 1 switch region, thus making it accessible for switch recombination.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-1097525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-2425035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-2836428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3007121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-301174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3038529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3081433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3081649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3086872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3106486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3132612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3315970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3319189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3491327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3495594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-3939752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6092053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6174872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6215332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6278424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6292864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6438635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6439816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6765193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6774415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6788376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-6804095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785916-881736
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
483-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2785916-Animals,
pubmed-meshheading:2785916-B-Lymphocytes,
pubmed-meshheading:2785916-Female,
pubmed-meshheading:2785916-Genes, Immunoglobulin,
pubmed-meshheading:2785916-Genes, Regulator,
pubmed-meshheading:2785916-Genes, Switch,
pubmed-meshheading:2785916-Immunoglobulin G,
pubmed-meshheading:2785916-Interleukin-4,
pubmed-meshheading:2785916-Interleukins,
pubmed-meshheading:2785916-Lipopolysaccharides,
pubmed-meshheading:2785916-Lymphocyte Activation,
pubmed-meshheading:2785916-Mice,
pubmed-meshheading:2785916-Mice, Inbred Strains,
pubmed-meshheading:2785916-Transcription, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4.
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pubmed:affiliation |
Institut für Genetik der Universität zu Köln, FRG.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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