Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-6-20
pubmed:abstractText
Twenty-eight cases of cutaneous T cell lymphomas of mycosis fungoides type, 8 of which showed a marked epidermotropism, were investigated for their reactivity with the monoclonal antibody HML-1. This reagent selectively recognizes human benign and malignant intestinal T lymphocytes, but not benign or malignant lymph node T cells. In all cases, the majority of nonepithelium-associated T cells present in the corium were HML-1 negative. In the eight cases with marked epidermotropism, the intraepidermal (IED) T cells were HML-1 positive in three cases, and HML-1 negative in the remaining five cases. The HML-1 positive IED T cells tended to be localized preferentially in the basal layers, whereas the HML-1 negative IED T cells were more diffusely distributed throughout all epidermal cell layers or formed intra-epidermal aggregates. These findings provide further evidence that mycosis fungoides is not a single entity, but represents a group of neoplasms originating from different T cell subsets that have in common their tropism to epidermis and/or dermis, and thus have a similar clinical presentation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-123432, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-145087, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-2409348, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-2415582, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-2415631, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-2858391, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-2873198, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-2903281, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-2936822, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-3004743, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-3005395, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-3108413, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-31410, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-3498635, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-3518522, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-3893149, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-4061384, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-4255245, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-445521, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-6129274, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-6198355, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-6345034, http://linkedlifedata.com/resource/pubmed/commentcorrection/2785762-6425398
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
955-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Reactivity of T cells in mycosis fungoides exhibiting marked epidermotropism with the monoclonal antibody HML-1 that defines a membrane molecule on human mucosal lymphocytes.
pubmed:affiliation
Institut für Pathologie, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't