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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0017968,
umls-concept:C0024518,
umls-concept:C0332120,
umls-concept:C1136158,
umls-concept:C1511938,
umls-concept:C1527148,
umls-concept:C1527178,
umls-concept:C1705938,
umls-concept:C1947978,
umls-concept:C2347644
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pubmed:issue |
5
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pubmed:dateCreated |
1989-6-9
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pubmed:abstractText |
T cells recognize foreign antigens together with those MHC glycoproteins they have encountered during their development in the thymus. How the repertoire of antigen-specific TCRs is selected has not yet been fully defined. We have investigated the T cell repertoire specificities of CD4-CD8+ cytotoxic T cells developing under conditions where one of the class I MHC-encoded molecules is blocked, while other class I-MHC glycoproteins are still expressed. We show that antigen-specific T cells restricted to the blocked class I fail to develop, while generation of other class I-specific T cell proceeds undisturbed. This highly selective perturbation of the T cell receptor repertoire demonstrates that development of CD4-CD8+ T cells with a certain TCR specificity requires expression of particular alleles of class I MHC. Thus, TCR-MHC interactions provide signals essential to the differentiation of precursor T cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-109568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-109569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-2421164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-2580891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-2950524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-2962352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-2965721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-2970593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3027582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3156439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3258650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3259290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3259471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3260350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3261392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3261843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3262831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3280468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3282008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3471350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3553374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3878228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-3921649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-567555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6120202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6181166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6185617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6226585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6234599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6333986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6415170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6459401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-6601175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-7135466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2785580-83702
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1619-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2785580-Animals,
pubmed-meshheading:2785580-Animals, Newborn,
pubmed-meshheading:2785580-Antibodies, Monoclonal,
pubmed-meshheading:2785580-Cell Differentiation,
pubmed-meshheading:2785580-Glycoproteins,
pubmed-meshheading:2785580-H-2 Antigens,
pubmed-meshheading:2785580-Immunization, Passive,
pubmed-meshheading:2785580-Mice,
pubmed-meshheading:2785580-Mice, Inbred BALB C,
pubmed-meshheading:2785580-Mice, Inbred C3H,
pubmed-meshheading:2785580-Receptors, Antigen, T-Cell,
pubmed-meshheading:2785580-Spleen,
pubmed-meshheading:2785580-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2785580-Thymus Gland,
pubmed-meshheading:2785580-Trinitrobenzenes
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pubmed:year |
1989
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pubmed:articleTitle |
Preferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development. Evidence for positive selection.
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pubmed:affiliation |
Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article
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