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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1989-6-22
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pubmed:abstractText |
Stromal cell lines derived from murine bone marrow support the growth of immature pre-B cells and produce cytokines that affect the growth and differentiation of other hematopoietic precursors. Conditioned medium (CM) from one such line (TC-1) stimulated marked proliferation of B cells previously activated by anti-Ig (anti-Ig blasts). Proliferation of anti-Ig blasts was not induced by purified cytokines known to be produced by TC-1 (CSF-1, GM-CSF, or G-CSF) or by IL-1, IL-2, IL-3, IL-4, IL-5, or IL-6. Furthermore, IL-2, IL-4, and IL-5, alone or in combination, failed to support proliferation or differentiation of anti-Ig blasts. TC-1 CM enhanced proliferation of B cells that were co-cultured with LPS, anti-Ig, or dextran sulfate; co-stimulation with anti-Ig was unaffected by the presence of monoclonal anti-IL-4. Proliferation of low, but not high, density B cells isolated from spleen was directly stimulated by TC-1 CM. These results suggest that bone marrow stromal cells produce a novel B cell stimulatory factor (BSF-TC) that induces proliferation of activated B cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3894-900
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2785568-Animals,
pubmed-meshheading:2785568-Antibodies, Anti-Idiotypic,
pubmed-meshheading:2785568-B-Lymphocytes,
pubmed-meshheading:2785568-Bone Marrow,
pubmed-meshheading:2785568-Cell Line,
pubmed-meshheading:2785568-Culture Media,
pubmed-meshheading:2785568-Drug Synergism,
pubmed-meshheading:2785568-Extracellular Matrix,
pubmed-meshheading:2785568-Growth Substances,
pubmed-meshheading:2785568-Interleukin-4,
pubmed-meshheading:2785568-Interleukins,
pubmed-meshheading:2785568-Interphase,
pubmed-meshheading:2785568-Lymphocyte Activation,
pubmed-meshheading:2785568-Lymphokines,
pubmed-meshheading:2785568-Mice,
pubmed-meshheading:2785568-Mice, Inbred BALB C
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pubmed:year |
1989
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pubmed:articleTitle |
Detection and characterization of a B cell stimulatory factor (BSF-TC) derived from a bone marrow stromal cell line.
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pubmed:affiliation |
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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