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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1989-6-6
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pubmed:abstractText |
A series of halogenated racemic analogues of dexetimide (1) was synthesized and their affinity for the muscarinic cholinergic receptor measured. One analogue, 4-iododexetimide (21), was efficiently labeled with 125I and 123I at high specific activity. In vitro binding studies and in vivo biodistribution studies suggest that 123I-labeled 21 may be useful for imaging muscarinic cholinergic receptors in the living human brain with single photon emission computed tomography.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
|
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pubmed:issn |
0022-2623
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
32
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1057-62
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2785211-Animals,
pubmed-meshheading:2785211-Dexetimide,
pubmed-meshheading:2785211-Iodine Radioisotopes,
pubmed-meshheading:2785211-Isotope Labeling,
pubmed-meshheading:2785211-Male,
pubmed-meshheading:2785211-Mice,
pubmed-meshheading:2785211-Parasympatholytics,
pubmed-meshheading:2785211-Piperidines,
pubmed-meshheading:2785211-Receptors, Muscarinic,
pubmed-meshheading:2785211-Tomography, Emission-Computed
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pubmed:year |
1989
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|
pubmed:articleTitle |
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.
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pubmed:affiliation |
Division of Nuclear Medicine and Radiation Health Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205-2179.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
