| pubmed-article:2785132 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C1882714 | lld:lifeskim |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C0151746 | lld:lifeskim |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C0282056 | lld:lifeskim |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2785132 | lifeskim:mentions | umls-concept:C1549542 | lld:lifeskim |
| pubmed-article:2785132 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2785132 | pubmed:dateCreated | 1989-5-31 | lld:pubmed |
| pubmed-article:2785132 | pubmed:abstractText | The pathogenesis of SLE is commonly attributed to the deposition of circulating immune complexes consisting of DNA and anti-DNA autoantibodies. However, recent work has shown multiple cross-reactions between anti-DNA antibodies and a variety of cellular and extracellular Ag. To test the possibility that these antibodies interact directly with glomerular Ag and induce kidney dysfunction, we applied mouse and human anti-DNA IgG to the isolated perfused rat kidney. The NZB/NZW mouse monoclonal anti-DNA bound to glomerular Ag with a concomitant induction of proteinuria and a decrease in inulin clearance. The albumin excretion was 2301 +/- 734 micrograms/min at 160 min of perfusion, as compared with 85 +/- 21 micrograms/min in controls (p less than 0.001). The inulin clearance was reduced to 0.17 +/- 0.02 ml/min as compared with 0.28 +/- 0.09 ml/min in controls (p less than 0.05). Polyclonal anti-DNA IgG obtained from patients with lupus nephritis bound to rat glomeruli and induced albumin excretion of 542 +/- 217 micrograms/min at 160 min of perfusion, as compared with 163 +/- 77 micrograms/min in controls (p = NS). The addition of plasma as a source of C to the human IgG increased the proteinuria markedly (albumin excretion of 1115 +/- 195 micrograms/min at 160 min of perfusion, p less than 0.02), probably due to C activation. Preincubation of the reactive mouse and human IgG with DNA completely abolished their binding to renal tissue and its physiologic consequences. These results suggest that direct binding of anti-DNA antibodies to renal Ag may play an important role in the induction of lupus nephritis. | lld:pubmed |
| pubmed-article:2785132 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2785132 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2785132 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2785132 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2785132 | pubmed:month | May | lld:pubmed |
| pubmed-article:2785132 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2785132 | pubmed:author | pubmed-author:RaoNN | lld:pubmed |
| pubmed-article:2785132 | pubmed:author | pubmed-author:RosenmannEE | lld:pubmed |
| pubmed-article:2785132 | pubmed:author | pubmed-author:EilatDD | lld:pubmed |
| pubmed-article:2785132 | pubmed:author | pubmed-author:BrezisMM | lld:pubmed |
| pubmed-article:2785132 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2785132 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2785132 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:2785132 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2785132 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2785132 | pubmed:pagination | 3076-82 | lld:pubmed |
| pubmed-article:2785132 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:2785132 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2785132 | pubmed:articleTitle | Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney. | lld:pubmed |
| pubmed-article:2785132 | pubmed:affiliation | Department of Medicine, Hadassah University Hospitals, Jerusalem, Israel. | lld:pubmed |
| pubmed-article:2785132 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2785132 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2785132 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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