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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-5-2
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pubmed:abstractText |
The capacity of rat brain capillary endothelium to present antigen to primed peripheral lymph node cells or to ovalbumin-specific T-cell lines was examined in vitro. Brain endothelium can present antigen, but it is generally ineffective at stimulating T-cell division. Division is only seen when indomethacin is included in the cultures to suppress eicosanoid production. Even under these conditions an endothelial monolayer is only 1/40 as effective as a thymocyte monolayer in stimulating division. The failure to act as an effective antigen presenting tissue is not due to lack of IL-1 production, nor is it related to the extended time required to induce MHC class II molecules on these cells. In the presence of high levels of antigen-specific T cells, the endothelium appears to be subject to cytotoxic damage, so that T-cell stimulation is lowest with higher numbers of T cells--the opposite of that seen with conventional antigen-presenting cells. These findings support the view that brain endothelial cells are not important in stimulating T-cell division during the development of immune reactions in brain, although these cells may be recognizable by class II-restricted cytotoxic cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-2415627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-2423637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-2435831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-2453456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-2465626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-2580013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-2941704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3084638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3106198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3110208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3139550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3487617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3493287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3495802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3873291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3890237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3897464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-3921611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-4322078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-6202848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-6397428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-6433204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-6692938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-6943285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784409-6982921
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-12
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1989
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pubmed:articleTitle |
Antigen presentation in brain: brain endothelial cells are poor stimulators of T-cell proliferation.
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pubmed:affiliation |
Department of Neuropathology, Institute of Psychiatry, London, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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