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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1989-4-4
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pubmed:abstractText |
Immunologic and antitumor effects of human recombinant interleukin-2 was studied in patients with advanced renal cell carcinoma. Intravenous drip infusion for inpatients or subsequent subcutaneous injection for outpatients at a daily dose of 1 x 10(6) units of interleukin-2 was given over a period varying from twenty-one to two hundred forty days to 13 patients. Natural killer cell activity increased 20 percent or more in 11 of the 13 patients, and lymphokine-activated killer cell activity increased 40 percent or more in 9 of the patients tested. Interleukin-2-receptor positive cells and HLA-DR positive cells in peripheral blood lymphocytes increased in 12 and 11 patients, respectively. Two patients achieved complete response; 1 had a partial response; 6 had no change; and 2 had progressive disease. Two patients were not evaluated because the therapy had been discontinued in less than four weeks. We conclude that low-dose interleukin-2 enhances patients' immunity and has a potential antitumor activity against renal cell carcinoma.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0090-4295
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
219-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2784018-Adult,
pubmed-meshheading:2784018-Aged,
pubmed-meshheading:2784018-Carcinoma, Renal Cell,
pubmed-meshheading:2784018-Cytotoxicity, Immunologic,
pubmed-meshheading:2784018-Female,
pubmed-meshheading:2784018-HLA-DR Antigens,
pubmed-meshheading:2784018-Humans,
pubmed-meshheading:2784018-Infusions, Intravenous,
pubmed-meshheading:2784018-Injections, Subcutaneous,
pubmed-meshheading:2784018-Interleukin-2,
pubmed-meshheading:2784018-Kidney Neoplasms,
pubmed-meshheading:2784018-Killer Cells, Natural,
pubmed-meshheading:2784018-Leukocyte Count,
pubmed-meshheading:2784018-Lymphocytes,
pubmed-meshheading:2784018-Male,
pubmed-meshheading:2784018-Middle Aged,
pubmed-meshheading:2784018-Receptors, Interleukin-2,
pubmed-meshheading:2784018-Recombinant Proteins
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pubmed:year |
1989
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pubmed:articleTitle |
Immunologic study of human recombinant interleukin-2 (low-dose) in patients with advanced renal cell carcinoma.
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pubmed:affiliation |
Department of Urology, School of Medicine, Keio University, Tokyo, Japan.
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|