Linked Life Data

2783068

Source:http://linkedlifedata.com/resource/pubmed/id/2783068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1989-10-16
pubmed:abstractText
Pigmented rabbits were anesthetized and given an intravitreous injection of 0.1 mL of a test substance or vehicle alone. Vitreous fluorophotometry was performed before injections and at various time points after injections. Compared with pretreatment scans, vehicle-injected eyes showed no change in intravitreous fluorescein sodium leakage at 6 and 24 hours after injection. Injection of adenosine (10(-2) mol/L) resulted in fluorescein leakage that was significantly greater than that which occurred in control eyes at 6 hours after injection, but returned to baseline at 24 hours. This effect was significantly attenuated by an adenosine receptor antagonist (BW-A1433U), suggesting that it was mediated by specific adenosine receptors. A nonselective adenosine receptor agonist, N-ethylcarboxamidoadenosine, and two relatively A1 selective receptor agonists, N6-cyclopentyladenosine and N6-phenylisopropyladenosine, also caused dose-dependent intravitreous fluorescein leakage. The relative order of potency was N-ethylcarboxamidoadenosine much greater than N6-phenylisopropyladenosine, which was greater than N6-cyclopentyladenosine, implicating A2 adenosine receptors. Intravitreous injection of dipyridamole, an adenosine uptake inhibitor, caused enhanced fluorescein leakage, presumably from extracellular accumulation of endogenous adenosine. The results of this study suggest that adenosine may be a mediator of blood-retinal barrier breakdown.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-9950
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1364-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Intravitreous injection of adenosine or its agonists causes breakdown of the blood-retinal barrier.
pubmed:affiliation
Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville 22908.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't