Linked Life Data

2779613

Source:http://linkedlifedata.com/resource/pubmed/id/2779613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-10-23
pubmed:abstractText
The antifungal activity of a new semi-synthetic lipopeptide named cilofungin (LY-121019) was studied in vitro on 102 strains of Candida and Torulopsis glabrata. A standardized protocol for susceptibility testing by means of a microtiter Sabouraud broth dilution was used. The minimal inhibitory concentrations of cilofungin for C. albicans (N = 50) ranged from 0.039 to 5.0 micrograms/ml with a geometric mean of 0.47 micrograms/ml. The same results were obtained with C. tropicalis but one strain showed higher resistance (40 micrograms/ml) suggesting an Eagle effect. The MIC for T. glabrata ranged from 5.0-40.0 micrograms/ml. C. parapsilosis and C. krusei were less susceptible (5.0-40.0 micrograms/ml). These results indicate that cilofungin exhibits a potent inhibitory action on C. albicans and C. tropicalis. This effect was lower against the other species of Candida and T. glabrata studied.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0933-7407
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
316-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Susceptibility of Candida species to cilofungin (LY-121019).
pubmed:publicationType
Journal Article