Linked Life Data

2778803

Source:http://linkedlifedata.com/resource/pubmed/id/2778803

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-10-25
pubmed:abstractText
Effects of a newly introduced polyoxyethylene-modified superoxide dismutase (SOD-POE) with prolonged plasma half life (10 h) on reperfusion induced arrhythmias were examined using a 15 min left anterior descending coronary artery (LAD) occlusion followed by reperfusion in the isolated perfused rat and guinea-pig hearts. LAD occlusion was performed by compressing the artery using a suction cup placed on the LAD to which negative pressure was applied. The LAD occlusion was repeated twice at an interval of 20 min. Drugs were infused from 10 min prior to the occlusion to 3 min after reperfusion at either first or second trial of the occlusion and release. ECG was monitored throughout the experiments. In the control group (rat hearts), arrhythmias including ventricular fibrillation (Vf) (incidence, 64.3 to 83.3%), ventricular tachycardia (VT) (66.7 to 84.6%), premature ventricular contraction (PVC) and premature atrial contraction (PAC) occurred immediately after reperfusion and lasted for 1 to 3 min. In both groups treated with SOD-POE (10 U/ml) or native human SOD (10 U/ml), the incidence of Vf and VT was 0% and the number of PVCs significantly decreased. Lidocaine (5 x 10(-7) M, 10(-6) M) also reduced the incidence of VT and the number of PVCs. In guinea-pig hearts, the occlusion and release induced Vf (50%), VT (80%), PVCs and PACs. Both SOD-POE and SOD markedly depressed the incidence of Vf (0%) and VT (14.3% in both groups) and decreased the number of PVCs and PACs. Results demonstrate that SOD-POE has the same pharmacological activity as SOD does in preventing reperfusion induced arrhythmias in isolated rat and guinea-pig hearts, suggesting that it will provide a novel therapeutic approach for preventing oxygen radical-related injury in myocardium and other tissues.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
441-52
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effects of polyoxyethylene-modified superoxide dismutase on reperfusion induced arrhythmias in isolated rat and guinea-pig hearts.
pubmed:affiliation
Department of Pharmacology, Kumamoto University Medical School, Honjo, Japan.
pubmed:publicationType
Journal Article, Comparative Study