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pubmed:abstractText |
Two hexapeptides NH2-Lys-Asp-Arg-Cys-Lys-Pro-COOH and NH2-Asp-Cys-Arg-Glu-Thr-Gly-COOH corresponding to the strong hydrophilic regions 37-42 and 83-88, respectively, on ribonuclease A were synthesized by solid-phase method. These synthetic peptides showed antigenic characteristics and provided an experimental validity to the prediction made earlier, supporting the view that highly hydrophilic regions on the protein have a good correlation with their being potentially antigenic.
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