Linked Life Data

2776294

Source:http://linkedlifedata.com/resource/pubmed/id/2776294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-10-19
pubmed:abstractText
The origins of strain and sex differences in the number of granule cells in the dentate area of hippocampus were examined in a breeding study employing two inbred strains of mice that differ substantially in granule cell number. Sources of hereditary variation analyzed included autosomes, sex chromosomes, and maternal factors, including cytoplasmic and environmental. The results corroborated those of an earlier study in finding that 80% of the strain variation is attributable to autosomal differences. In addition, there appears to be a cytoplasmic factor that results in a strain-dependent sex dimorphism. The autosomal contribution is attributed to mechanisms operating during the primary phase of granule cell genesis. The possibility that the sex difference results from strain differences in mitochondrial DNA affecting rate of cell death is considered.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-76
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
On the sources of strain and sex differences in granule cell number in the dentate area of house mice.
pubmed:affiliation
Section of Behavioral and Neural Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.