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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1989-9-29
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pubmed:abstractText |
This paper considers a proportional hazards model that describes the relationship between time-dependent cumulative dose of drug and development of toxicity. We estimate probabilities of developing toxicity in both the presence and the absence of competing risks and provide variances for the latter case. Mitoxantrone data collected in Southwest Oncology Group studies illustrate the methods.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0277-6715
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
813-23
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2772441-Adult,
pubmed-meshheading:2772441-Aged,
pubmed-meshheading:2772441-Aged, 80 and over,
pubmed-meshheading:2772441-Antineoplastic Agents,
pubmed-meshheading:2772441-Clinical Trials as Topic,
pubmed-meshheading:2772441-Dose-Response Relationship, Drug,
pubmed-meshheading:2772441-Drug Evaluation,
pubmed-meshheading:2772441-Female,
pubmed-meshheading:2772441-Humans,
pubmed-meshheading:2772441-Male,
pubmed-meshheading:2772441-Mitoxantrone,
pubmed-meshheading:2772441-Models, Statistical,
pubmed-meshheading:2772441-Neoplasms,
pubmed-meshheading:2772441-Probability,
pubmed-meshheading:2772441-Risk
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pubmed:year |
1989
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pubmed:articleTitle |
A method for the evaluation of dose-toxicity relationships in clinical trials.
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pubmed:affiliation |
Department of Biostatistics and Epidemiology, Tulane University Medical Center, New Orleans, LA 70112.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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