Linked Life Data

2772408

Source:http://linkedlifedata.com/resource/pubmed/id/2772408

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-9-25
pubmed:abstractText
A study was undertaken in goats to investigate the ability of two unrelated stocks of Trypanosoma congolense, one of which is highly sensitive to isometamidium chloride and one which is drug-resistant, to become established in the presence of an existing infection with the other stock. The goats, which were initially infected with the sensitive strain and were then challenged with the resistant strain, were cured by treatment at 0.1 mg kg-1 isometamidium, indicating that the resistant stock did not establish an infection. Goats initially infected with the resistant stock, which were then challenged with the sensitive stock, experienced temporary remission of infection followed by relapse after treatment at 0.1 mg kg-1 isometamidium. In contrast, the goat infected only with the resistant stock remained parasitaemic following treatment at 0.1 mg kg-1. This suggests that superinfection with the sensitive stock resulted in the establishment of infection, which suppressed the resistant stock to below the limit of detection of the method used. These observations suggest that isometamidium-resistant stocks may be less viable than sensitive strains, and could explain the relative scarcity of isometamidium resistant in the field.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0034-5288
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Interference between drug-resistant and drug-sensitive stocks of Trypanosoma congolense in goats.
pubmed:affiliation
University of Glasgow Veterinary School.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't