Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-10-12
pubmed:abstractText
It is reported on the preparation and investigation of matrix tablets on the basis of the polylactic acid. Caffeine and phenazone served as model drugs. The release values obtained were analyzed by the equations of Noyes-Whitney and of Higuchi. It was demonstrated, that the solubility and the grain size of the drugs, their content in the tablets and an addition of Heweten 12 have an influence of the release of the drugs. In in vitro-investigations can be shown a hydrolytic degradation of the polymer, but not an enzymatic degradation.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
328-30
pubmed:dateRevised
2007-1-29
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Preparation of oral sustained-action preparations with a base of biologically degradable polymers. 2. Preparation of matrix tablets with a base of polylactic acid].
pubmed:affiliation
Sektion Chemie, Wissenschaftsbereich Pharmazie, Humboldt-Universität zu Berlin.
pubmed:publicationType
Journal Article, English Abstract