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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1989-10-10
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pubmed:abstractText |
Mice experimentally infected with Schistosoma curassoni were treated with different dose regimens of praziquantel, metrifonate, oxamniquine and hycanthone. Praziquantel was the most effective drug; a dose of 100 mg/kg given orally for 5 days resulted in a 95% reduction in worm burdens. The drug produced oogram changes in all animals. Metrifonate did not result in a reduced worm burden but caused oogram changes even on a low-dose (150 mg/kg during 2 consecutive days) schedule. Oxamniquine proved to be ineffective; no reduction in worm burdens or alterations in oograms were observed. Hycanthone (80 mg/kg for 1 day) resulted in a significant reduction in worm burdens.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
0932-0113
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
559-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2771923-Animals,
pubmed-meshheading:2771923-Disease Models, Animal,
pubmed-meshheading:2771923-Female,
pubmed-meshheading:2771923-Hycanthone,
pubmed-meshheading:2771923-Male,
pubmed-meshheading:2771923-Mice,
pubmed-meshheading:2771923-Nitroquinolines,
pubmed-meshheading:2771923-Oxamniquine,
pubmed-meshheading:2771923-Praziquantel,
pubmed-meshheading:2771923-Schistosomiasis,
pubmed-meshheading:2771923-Thioxanthenes,
pubmed-meshheading:2771923-Trichlorfon
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pubmed:year |
1989
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pubmed:articleTitle |
Experimental chemotherapy of Schistosoma curassoni in mice.
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pubmed:affiliation |
Department of Parasitology, Faculty of Veterinary Medicine, Gent, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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