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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1989-10-6
|
| pubmed:abstractText |
The purpose of this study was the quantitative assessment of mucosal inflammation and its relationship to Campylobacter pylori in gastric antral and body biopsies from patients with dyspepsia and controls. The study groups comprised patients with duodenal ulcer (DU; n = 20), duodenitis (DUN; n = 20), non-ulcer dyspepsia (NUD; n = 20). Using a semi-automatic, computer-linked image analyser (Kontron: MOP Videoplan), mucosal acute and chronic inflammatory cell densities were measured in defined gastric sites for each patient group and expressed as number per mm2 of lamina propria and number per mm length of epithelium. Measurements were also made on a group of asymptomatic controls (n = 9) who fulfilled strict exclusion criteria. All biopsies were analysed for the presence of Camplyobacter pylori (CP) with a Giemsa stain. Data between groups were compared using the Mann-Whitney U-test. In the antrum and body, the mononuclear cell count was significantly higher in lamina propria in DU patients than in DUN, NUD and controls. In the body, DU laminia propria mononuclear cell counts were higher than those of DUN and controls. Prevalence rates for CP for DU, DUN, and NUD were 94, 89, and 50 per cent for antral and 88, 83, and 56 per cent for body biopsies. Significant differences were present between CP-positive and negative subjects in the NUD group. Antral and body inflammation within these clinical groups shows a wide variation. Higher inflammatory cell counts in the DU group may reflect the prevalence of CP colonization.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-3417
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
158
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
303-10
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2769489-Adult,
pubmed-meshheading:2769489-Campylobacter,
pubmed-meshheading:2769489-Duodenal Ulcer,
pubmed-meshheading:2769489-Duodenitis,
pubmed-meshheading:2769489-Dyspepsia,
pubmed-meshheading:2769489-Female,
pubmed-meshheading:2769489-Gastric Mucosa,
pubmed-meshheading:2769489-Gastritis,
pubmed-meshheading:2769489-Humans,
pubmed-meshheading:2769489-Image Processing, Computer-Assisted,
pubmed-meshheading:2769489-Male,
pubmed-meshheading:2769489-Pyloric Antrum
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Superficial gastritis and Campylobacter pylori in dyspeptic patients--a quantitative study using computer-linked image analysis.
|
| pubmed:affiliation |
Department of Medicine, Queen's University of Belfast, Northern Ireland.
|
| pubmed:publicationType |
Journal Article
|