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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1989-10-4
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pubmed:abstractText |
Five vascularised allografts of the knee joint were performed in dogs immunosuppressed with cyclosporin A and azathioprine. Three survived with normal function for 3 to 4 months after operation. One of the unsuccessful grafts had a failed vascular anastomosis, the other an inadequate blood level of cyclosporin A. All three successful grafts healed well. In two, bone scans, radiographs and biopsies were indistinguishable from successful autografts; in the third the blood supply to the graft failed despite patent anastomoses but the graft healed well with good function. All three grafts were rejected within 2 to 3 weeks of withdrawal of cyclosporin A and azathioprine. In non-immunosuppressed dogs, allografts of the knee, both vascularised and non-vascularised, were rejected within a few days of operation. In two non-vascularised allografts, administration of cyclosporin and azathioprine had no apparent effect on the rate of rejection of the graft.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0301-620X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
576-82
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pubmed:dateRevised |
2010-11-10
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pubmed:meshHeading |
pubmed-meshheading:2768300-Animals,
pubmed-meshheading:2768300-Azathioprine,
pubmed-meshheading:2768300-Bone and Bones,
pubmed-meshheading:2768300-Cartilage, Articular,
pubmed-meshheading:2768300-Cyclosporins,
pubmed-meshheading:2768300-Dogs,
pubmed-meshheading:2768300-Graft Survival,
pubmed-meshheading:2768300-Immunosuppression,
pubmed-meshheading:2768300-Knee Joint,
pubmed-meshheading:2768300-Vascular Patency
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pubmed:year |
1989
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pubmed:articleTitle |
The effect of immunosuppression on vascularised allografts. A preliminary report.
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pubmed:affiliation |
St Vincent's Hospital, Melbourne.
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pubmed:publicationType |
Journal Article
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