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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
1989-10-5
|
| pubmed:abstractText |
Development of resistance to hormonal therapy in breast cancer is frequently associated with a decline or loss of cellular estrogen receptors. Agents which up-regulate the receptor may reduce the incidence of hormonal resistance. Antiestrogens at concentrations ranging from 0.1 to 1 microM produced a 2- to 4-fold increase of estrogen receptors in MCF-7 and T-47D breast cancer cells. This increase, which occurred as early as 3 h and was sustained throughout the 4 days of continuous exposure to tamoxifen, was primarily due to an enhancement in receptor synthesis.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5312-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2766299-Breast Neoplasms,
pubmed-meshheading:2766299-Cycloheximide,
pubmed-meshheading:2766299-Dose-Response Relationship, Drug,
pubmed-meshheading:2766299-Humans,
pubmed-meshheading:2766299-Receptors, Estrogen,
pubmed-meshheading:2766299-Tamoxifen,
pubmed-meshheading:2766299-Time Factors
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Up-regulation of estrogen receptors by nonsteroidal antiestrogens in human breast cancer.
|
| pubmed:affiliation |
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|